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(2E)-2-({(2S)-2-carboxy-2-[(phenoxyacetyl)amino]ethoxy}imino)pentanedioic acid
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule with the IUPAC name (2E)-2-{[(2S)-2-carboxy-2-(phenoxyacetamido)ethoxy]imino}pentanedioic acid. It has been studied as an experimental inhibitor of penicillin-binding proteins (PBPs), which are essential enzymes involved in bacterial cell wall synthesis. The compound is structurally related to lactivicins, a class of non-beta-lactam antibiotics that mimic the D-Ala-D-Ala terminus of peptidoglycan precursors and inhibit PBPs by covalent binding to their active site serine residues. This mechanism disrupts cell wall biosynthesis, leading to antibacterial effects[7][1][2]. Its primary research context has been structural and mechanistic studies rather than clinical development.
- Other names
- (2E)-2-{[(2S)-2-carboxy-2-(phenoxyacetamido)ethoxy]imino}pentanedioic acidDB08401DB-08401DB 08401
02
Targets
PBP1b (Penicillin-binding protein 1B)
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